Bronchiectasis (BE) lungs illustration

BRINSUPRI targets a key driver of bronchiectasis

BRINSUPRI is a once-daily pill and the only approved bronchiectasis treatment that targets inflammation caused by neutrophils

In caused by overactive immune cells, called can your lungs and increase your risk of

Watch how BRINSUPRI helps target inflammation

Bronchiectasis is a chronic lung disease where the airways become abnormally widened. People living with bronchiectasis often experience periods of time when symptoms like coughing, fatigue, and shortness of breath get worse.

[onscreen text]: FLARE

These bronchiectasis flares, or exacerbations, can be unpredictable, lead to even more flares, and can cause worsening of the disease.

Let’s take a look.

[onscreen text]: BRONCHIECTASIS

In bronchiectasis, the airways are widened, making it hard to clear mucus from the lungs.

This environment can cause bacteria to grow, which puts the lungs at risk for ongoing infection, inflammation, and damage.

The body’s defense system responds by sending immune cells—including neutrophils—to address trouble in the airways.

[onscreen text]: NEUTROPHILS

Think of these neutrophils as helpers that release enzymes to fight infection. But when you have bronchiectasis, your body sends many of these neutrophils to the lungs. And these neutrophils overreact by releasing too many infection-fighting enzymes.

[onscreen text]: OVERREACT

The presence of too many enzymes can contribute to ongoing inflammation in the lungs and bronchiectasis flares, which can be damaging.

[onscreen text]: INFLAMMATION

[onscreen text]: BRINSUPRI Logo

But there's a way to help reduce this overreaction with BRINSUPRI, a once-daily pill approved to treat non-cystic fibrosis bronchiectasis.

[onscreen text]: REDUCES SPECIFIC ENZYMES

Over time, BRINSUPRI reduces the amount of specific enzymes that can contribute to ongoing inflammation in the lungs.

[onscreen text]: TARGETS INFLAMMATION

This allows BRINSUPRI to target inflammation.

[onscreen text]: THE ONLY FDA-APPROVED TREATMENT specifically for non-cystic fibrosis bronchiectasis

Once-daily BRINSUPRI is the only FDA-approved treatment specifically for non-cystic fibrosis bronchiectasis in people 12 years of age and older.

[onscreen text]: BRINSUPRI Logo

BRINSUPRI offers a different approach to treating bronchiectasis.

[onscreen text]: Talk to your pulmonologist to LEARN MORE ABOUT BRINSUPRI

Talk to your pulmonologist to learn more about BRINSUPRI.

BRINSUPRI offers you a different approach to treating bronchiectasis

If you’ve been experiencing bronchiectasis flares, BRINSUPRI may be able to help

See study results

IMPORTANT SAFETY INFORMATION AND INDICATION

Before taking BRINSUPRI, tell your healthcare provider about all of your medical conditions, including if you:

  • have recently received or are scheduled to receive any live attenuated vaccinations.

  • are pregnant or plan to become pregnant. It is not known if BRINSUPRI will harm your unborn baby.

  • are breastfeeding or plan to breastfeed. It is not known if BRINSUPRI passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not change or stop your medicines unless your healthcare provider tells you to.

BRINSUPRI may cause serious side effects including:

  • Skin problems. Tell your healthcare provider about any new skin symptoms. Your healthcare provider may send you to a dermatologist for an examination, if needed. 

  • Dental problems. Get regular dental checkups while taking BRINSUPRI. Brush and clean your teeth as recommended by your dentist. Tell your healthcare provider and contact your dentist if you experience new gum (gingival) or teeth (dental) symptoms.

Common side effects of BRINSUPRI

The most common side effects of BRINSUPRI include upper respiratory tract infection, headache, rash, dry skin, small areas of skin thickening (hyperkeratosis), and high blood pressure (hypertension).

Less common side effects include abnormal liver blood test, hair loss (alopecia), and skin cancers.

These are not all of the possible side effects of BRINSUPRI.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is BRINSUPRI?

BRINSUPRI is a prescription medicine used to treat non-cystic fibrosis bronchiectasis (NCFB) in adults and children 12 years of age and older. It is not known if BRINSUPRI is safe and effective in children under 12 years of age.

Please see full Prescribing Information and Patient Information.